The ENA (extractable nuclear antigen) panel is a blood test that looks for antibodies to 6 or 7 different proteins in the body.An extractable nuclear antigen (ENA) panel detects the presence of autoantibodies in the blood that react with proteins in the cell nucleus. … The ENA panel may be used as follow-up testing to a positive ANA test to help diagnose an autoimmune disorder. These antibodies include: anti-Ro (also called anti-SSA)